Margarette (Marg) Mariano

margarette.mariano [einsteinmed.edu]

Child's drawing of a girl with black hair, smiling, and wearing a yellow accessory, with the name 'Mary' written above.

Keywords: Vaccine Design, RNA viruses, immune responses, ori Tahiti, shopping

My current project in Jon Lai’s lab involves engineering proteins that protect against Dengue and Zika infections in vivo.

In the future, I'm interested in raising a large family in a large city in a modest, but decently decorated home, where I can host many gatherings with good food and good company. My hobbies and interests include Ori Tahiti, Hula, shopping, streaming services, cleaning, hosting events, and organizing.

Previous Education

University of California, Berkeley: College of Letter and Science, BS South and Southeast Asian Studies (emphasis in Filipino Language), BS Molecular and Cell Biology (emphasis in immunology)

University of San Francisco, MS Biology (virology and cancer)

Highlights

  • Publications

    • Huang, H.H., Ferguson, I.D., Thornton, A.M., Bastola, P., Lam, C., Lin, Y.-H.T., Choudhry, P., Mariano, M.C., Marcoulis, M.D., Teo, C.F., et al. (2020). Proteasome inhibitor-induced modulation reveals the spliceosome as a specific therapeutic vulnerability in multiple myeloma. Nature Communications 11, 1931

    • Choudhry, P., Mariano, M.C., Geng, H., Martin, T.G., 3rd, Wolf, J.L., Wong, S.W., Shah, N., and Wiita, A.P. (2020). DNA methyltransferase inhibitors upregulate CD38 protein expression and enhance daratumumab efficacy in multiple myeloma. Leukemia 34, 938-941.

    • Lin, Y.T., Way, G.P., Barwick, B.G., Mariano, M.C., Marcoulis, M., Ferguson, I.D., Driessen, C., Boise, L.H., Greene, C.S., and Wiita, A.P. (2019). Integrated phosphoproteomics and transcriptional classifiers reveal hidden RAS signaling dynamics in multiple myeloma. Blood Adv 3, 3214-3227.

    • Albao, D.S., Cutiongco-de la Paz, E.M., Mercado, M.E., Lirio, A., Mariano, M., Kim, S., Yangco, A., Melegrito, J., Wad-Asen, K., Gauran, II, et al. (2019). Methylation changes in the peripheral blood of Filipinos with type 2 diabetes suggest spurious transcription initiation at TXNIP. Hum Mol Genet 28, 4208-4218.

    • Lam, C., Ferguson, I.D., Mariano, M.C., Lin, Y.T., Murnane, M., Liu, H., Smith, G.A., Wong, S.W., Taunton, J., Liu, J.O., et al. (2018). Repurposing tofacitinib as an anti-myeloma therapeutic to reverse growth-promoting effects of the bone marrow microenvironment. Haematologica 103, 1218-1228.

    • Young, V.P., Mariano, M.C., Tu, C.C., Allaire, K.M., Avdic, S., Slobedman, B., and Spencer, J.V. (2017). Modulation of the Host Environment by Human Cytomegalovirus with Viral Interleukin 10 in Peripheral Blood. J Infect Dis 215, 874-882.

  • Conference Abstracts

    • Margarette Mariano, Vivian Young, Kathryn Allaire, Juliet Spencer; Detection of cmvIL-10 during Virus Infection and Implications for use as a Biomarker [abstract], In: 41st Annual International Herpesvirus Workshop; 2016 Jul 23-27; Madison, WI. Abstract 2.32.

    • Hector H Huang, Christine YT Lam, Alexis Thornton, Margarette Mariano, Ian Ferguson, Byron C Hann, Angela Brooks, and Arun P. Wiita; Unbiased Phosphoproteomics Reveals a Therapeutically Relevant Connection between Pre-mRNA Splicing and Proteasome Inhibition in Multiple Myeloma [abstract], In: American Society of Hematology 59th Annual Meeting and Exposition; 2017 Dec 9-12; Atlanta, GA. Washington, DC: ASH; 2017. Abstract 3069

    • Ian Ferguson, Christine Lam, Margarette C. Mariano, Donghui Wang, Paul Phojanakong, Sami Toumivaara, Hao Shao, Byron C Hann, Jason Gestwicki, Arun P Wiita. Novel Allosteric Inhibitors of Heat Shock Protein 70 As Agents to Probe Protein Homeostasis and Overcome Proteasome Inhibitor Resistance in Multiple Myeloma [abstract]. Blood. 2018 Nov 29; 132(Supplement 1):3212-3212.

  • Presentations

    • ASV 2021 ASV conference (Oral presentation)

    • GRC Chemistry and Biology of Peptides 2022 (Poster presentation)

    • Association of Philippine Physicians in America (APPA) National Convention 2022 (Oral presentation)

    • City of Hope’s 6th Annual Biomedical Research Graduate Student Symposium 2022 (Oral presentation), 1st place Oral presentation winner

    • Council of Young Filipinx Americans in Medicine (CYFAM) Annual Conference 2023 (Poster presentation)