Ken Haesslein

Keywords: ZIKV, DENV, Deep mutational scanning

I am currently performing deep mutation scanning on an engineered ZIKV glycoprotein immunogen with non-EDE epitopes masked by hyperglycosylation. I aim to identify residues critical for broadly neutralizing antibody binding to the E-dimer epitope. I hope to guide optimization of the engineered glycoprotein for use as a broadly protective ZIKV and DENV vaccine.

Outside of lab, I enjoy playing chess, going on walks/hikes and playing dungeons and dragons.