Ana Sofia Ferreira Ramos
Keywords: Alphavirus, Flavivirus, nanoparticles, CryoEM, mAbs, Single B-cell sorting, 10x Genomics
I am currently working on the development of alphavirus and flavivirus immunogens to elicit a protective broadly neutralizing response. Prior to the Lai lab, I completed my PhD at the University of Aix-Marseille specializing in structural biochemistry; I then spent 2 years working as a postdoctoral fellow at the Icahn School of Medicine at Mount Sinai with Dr. Goran Bajic. There, I worked on understanding how the interplay of a rapidly evolving virus and the host humoral immune system can lead to better vaccines.
I enjoy many outdoor activities, I like fishing, but usually not catching anything, whale and bird watching, and camping. When it is raining, I prefer to be indoors playing board games, doing puzzles, painting, and annoying cats. I also like to go to see movies and I enjoy science fiction movies like "Project: Hail Mary".
Previous Education
Ph.D. Health - Biology, specialization in Structural Biochemistry (Bruno Canard), Aix-Marseille University, Marseille, France 2019
M.S. Biochemistry, University of Porto, Porto, Portugal, 2013
B.S. Biology, University of Aveiro, Aveiro, Portugal, 2010
Selected Publications
Maurer DP, Vu M, Ramos ASF, Dugan HL, Khalife P, Geoghegan JC, Walker LM, Bajic G, Schmidt AG. Conserved sites on the influenza H1 and H3 hemagglutinin recognized by human antibodies. Sci Adv. 2025 Apr 25;11(17):eadu9140. doi: 10.1126/sciadv.adu9140. Epub 2025 Apr 23. PubMed PMID:40267182; PubMed Central PMCID: PMC12017299. PDBs: 9BDF and 9BDG
Feldman J, Ferreira Ramos AS, Vu M, Maurer D, Rosado V, Lingwood D, Bajic G, Schmidt A. Human naive B cells recognized pre-pandemic influenza virus hemagglutinins. Sci Immunol. 2025 Jan 24;10(103):eado9572. doi: 10.1126/sciimmunol.ado9572. Epub 2025 Jan 24. PubMed PMID:39854479. PDB: 8UME
Lahey-Rudolph J. M., Schonherr R., Jeffries C. M., Blanchet C. E., Boger J., Ferreira Ramos A. S., Riekehr W. M., Triandafillidis D. P., Valmas A., Margiolaki I., Svergun D., Redecke L. Rapid screening of in cellulo grown protein crystals via a small-angle X-ray scattering /X-ray powder diffraction synergistic approach. Journal of Applied Crystallography, (2020), 53, 1169 - 1180. DOI:10.1107/S1600576720010687.